Both chlorhexidine gluconate (CHG) and polyhexamethylene biguanide (PHMB) are commonly used
as antiseptics and have shown efficacy in infection prevention on human skin. However, there are
some differences between the two compounds. Here are the potential benefits of CHG over PHMB:
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1. Broader spectrum of activity: CHG has a broader spectrum of antimicrobial activity
compared to PHMB. It is effective against a wide range of bacteria, fungi, and some viruses,
including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant
Enterococcus (VRE). PHMB, on the other hand, has a narrower spectrum of activity and may
not be as effective against certain microorganisms.
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2. Persistent activity: CHG exhibits residual or persistent activity, meaning it continues to
provide antimicrobial protection even after it has dried on the skin. This residual activity can
last for several hours, providing prolonged protection against infection. PHMB, in contrast,
has limited residual activity and may require more frequent application for sustained
protection.
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3. Lower risk of resistance: CHG has a lower likelihood of promoting antimicrobial resistance
compared to PHMB. Prolonged or excessive use of PHMB can lead to the development of
bacterial resistance, limiting its long-term effectiveness. CHG has been used for many years
and resistance is less common.
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4. Greater availability and established use: CHG has been widely used in healthcare settings
and has an established track record of safety and efficacy. It is available in various
formulations such as soaps, wipes, and solutions, making it easily accessible for healthcare
professionals and patients. PHMB, while also used in certain products, may have a more
limited availability and may not be as widely recognized or utilized.
It's important to note that the choice of antiseptic depends on the specific situation, the type of
infection or procedure, and the recommendations of healthcare professionals. Different
formulations and concentrations of CHG and PHMB may also vary in their effectiveness. Therefore, it
is crucial to follow the guidance of healthcare providers and adhere to proper application techniques
and dosage recommendations for optimal infection prevention on human skin.